Mary Wakefield Mary Wakefield

What will you do in the gene-editing revolution?

Crispr could relieve tremendous suffering – and do great harm. Scientists need your sceptical attention

issue 11 March 2017

The only time I ever saw a wolf in the wild, a small one, I was so frightened that I closed my eyes. It was a useful insight into the depths of my own cowardice.

Every day, with each new story about the exciting breakthroughs we’re making in genetic engineering, I feel that same shameful urge to shut my eyes.

Far faster than anybody thought, we’re working out the genes responsible for all manner of traits in all creatures great and small. Far more easily than anyone expected, we’ve moved from standard gene therapies to figuring out how to actually edit our own DNA, to ferret around inside living cells, snipping out duff genes and replacing them.

Until recently it was mostly mice at (or under) the cutting edge of this new technology. But late last year, just as everyone in the West was agreeing that human trials were a mistake, China piped up and announced that it had injected ‘edited’ genes into a cancer sufferer.

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