Open and shut case: how did lockdown affect shops?

Shot in the arm

Global stock markets reached a new high after pharmaceutical firm Pfizer announced a vaccine it is developing has been found to be 90 per cent effective. What have been the best- and worst-performing FTSE 100 shares over the past 12 months?

BEST

Scot. Mortgage Investment Trust | +109%

Ocado | +94%

Fresnillo (gold production) | +86%

Flutter Entertainment | +75%

Polymetal | +51%

WORST

Rolls-Royce | -74%

Int. Consolidated Airlines | -71%

BP | -61%

Shell (B shares) | -58%

Lloyds Bank | -52%

Pharma’s life

Who was Mr Pfizer? Charles Pfizer set up a factory with his cousin Charles Erhart in Brooklyn in 1849, initially to produce the drug santonin, used to purge the intestinal tract of parasitic worms. They did not, however, discover the drug, which was first made in Germany in the 1830s using a plant called artemisia, from Turkmenistan. — In more recent times Pfizer was involved in manufacturing and supplying penicillin to US troops during the second world war.